November-December 2016| Vol 2| Issue 6
Choline kinase inhibitors synergize with TRAIL in the treatment of colorectal tumors and overcomes TRAIL resistance
Juan Carlos Lacal, Ladislav Andera
Aim: The aim of this study was to investigate the effects of the combination of choline kinase inhibitor MN58b and tumor necrosis factor-related apoptosis inducing ligand (TRAIL) against colon ...
MicroRNA regulating metabolic reprogramming in tumor cells: New tumor markers
Daniel Otero-Albiol, Blanca Felipe-Abrio
Metabolic reprogramming is a feature of cancer cells that provides fast energy production and the abundance of precursors required to fuel uncontrolled proliferation. The Warburg effect, increase in g...
Biomarkers of colorectal cancer: A genome-wide perspective
José M Santos-Pereira, Sandra Muñoz-Galván
Colorectal cancer (CRC) is one of the most common cancers in the world and one of the main causes of death. Although CRC is among the best-studied cancers and our knowledge about CRC biomarkers and ca...
Nicotinamide adenine dinucleotide+ metabolism biomarkers in malignant gliomas
Manuel P Jiménez-García, Eva M Verdugo-Sivianes, Antonio Lucena-Cacace
Gliomas are highly metabolically active tumors. Cancer metabolism is currently of great interest to researchers. Nicotinamide adenine dinucleotide (NAD) is central in cell metabolism. NAD+
Patient-derived xenografts as models for personalized medicine research in cancer
Marco Perez, Lola Navas, Amancio Carnero
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Basic research and clinical trials are essential components of the process of discovery and development of new drugs. The use of preclinical models is a key component in every aspect of drug developme...
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