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November-December 2016| Vol 2| Issue 6

  • Table of ContentsTable of Contents

Original Article

Choline kinase inhibitors synergize with TRAIL in the treatment of colorectal tumors and overcomes TRAIL resistance
Juan Carlos Lacal, Ladislav Andera

Aim: The aim of this study was to investigate the effects of the combination of choline kinase inhibitor MN58b and tumor necrosis factor-related apoptosis inducing ligand (TRAIL) against colon ...

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MicroRNA regulating metabolic reprogramming in tumor cells: New tumor markers
Daniel Otero-Albiol, Blanca Felipe-Abrio

Metabolic reprogramming is a feature of cancer cells that provides fast energy production and the abundance of precursors required to fuel uncontrolled proliferation. The Warburg effect, increase in g...

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Biomarkers of colorectal cancer: A genome-wide perspective
José M Santos-Pereira, Sandra Muñoz-Galván

Colorectal cancer (CRC) is one of the most common cancers in the world and one of the main causes of death. Although CRC is among the best-studied cancers and our knowledge about CRC biomarkers and ca...

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Nicotinamide adenine dinucleotide+ metabolism biomarkers in malignant gliomas
Manuel P Jiménez-García, Eva M Verdugo-Sivianes, Antonio Lucena-Cacace

Gliomas are highly metabolically active tumors. Cancer metabolism is currently of great interest to researchers. Nicotinamide adenine dinucleotide (NAD) is central in cell metabolism. NAD+

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Patient-derived xenografts as models for personalized medicine research in cancer
Marco Perez, Lola Navas, Amancio Carnero

Basic research and clinical trials are essential components of the process of discovery and development of new drugs. The use of preclinical models is a key component in every aspect of drug developme...

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